Nck-associated protein 1; NAP 1; membrane-associated protein HEM-2; p125Nap1 (NCKAP1, HEM2, KIAA0587, NAP1)

Function

• part of lamellipodia complex that controls Rac-dependent actin remodeling (putative)
• associates preferentially with the first SH3 domain of NCK
• component of the WAVE2 complex
• component of the WAVE1 complex

Structure

belongs to the HEM-1/HEM-2 family

Compartment

• cell membrane
• single-pass membrane protein cytoplasmic side (putative)
• cell projection, lamellipodia
• at the interface between the lamellipodia actin meshwork & the membrane (putative)

Alternative splicing

named isoforms=2

Expression

• expressed in most tissues
• highest expression in brain, heart, & skeletal muscle
• not expressed in peripheral blood leukocytes

More general terms

• Nck-associated protein (NAP)
• membrane protein

Additional terms

• nck adaptor protein
• Nck-associated protein 1-like (membrane-associated protein HEM-1, hematopoietic protein 1, NCKAP1L, HEM1)

Component of

• WAVE1 complex
• WAVE2 complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10787
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10787
• OMIM: https://mirror.omim.org/entry/604891
• UniProt: http://www.uniprot.org/uniprot/Q9Y2A7.html