Ras association domain-containing family protein 5 (new ras effector 1, regulator for cell adhesion & polarization enriched in lymphoid tissues, RAPL, RASSF5, NORE1, RAPL)

Function

• tumor suppressor (putative)
• lymphocyte adhesion by linking RAP1A activation upon T cell receptor or chemokine stimulation to integrin activation (putative)
• isoform 2
  • stimulates lymphocyte polarization & patch-like distribution of ITGAL/LFA-1, enhancing adhesion to ICAM1
  • association with activated RAP1A required for directional movement of endothelial cells during wound healing
  • inhibits STK4 autoactivation
• regulation of microtubule growth (in association with RAP1A)
• regulation of Ras apoptotic function (putative)
  • RASSF5-STK4 complex may mediate HRAS1 & KRAS induced apoptosis
• interacts with activated HRAS1, KRAS, RSSF1 isoform A
• putatively interacts with Ras-like GTPases RRAS, RRAS2, MRAS, RAP1B, RAP2A, RALA.
• self-associates

Compartment

• cytoplasm
• isoform 2 is located in perinuclear region of unstimulated primary T cells; upon stimulation translocates to the leading edge & colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse
• isoform 2 is localized to growing microtubules in vascular endothelial cells & is dissociated from microtubules by activated RAP1A

Alternative splicing

named isoforms=4

Expression

widely expressed

Pathology

• frequently down-regulated in lung tumor cell lines & primary lung tumors

More general terms

• zinc finger protein

Database

• OMIM: https://mirror.omim.org/entry/607020
• UniProt: http://www.uniprot.org/uniprot/Q8WWW0.html