Ras-related protein R-Ras2; Ras-like protein TC21; teratocarcinoma oncogene (RRAS2, TC21)

Function

• plasma membrane-associated GTP-binding protein with GTPase activity
• might transduce growth inhibitory signals across the cell membrane, via an effector shared with Ras proteins; effects are antagonistic to Ras proteins
• may be post-translationally modified by both palmitoylation & polyisoprenylation

Structure

belongs to the small GTPase superfamily, Ras family

Compartment

• cell membrane; lipid-anchor; cytoplasmic side (putative)
• inner surface of plasma membrane possibly with attachment requiring farnesylation of the C-terminal Cys (Caax motif)

Expression

• ubiquitously present in all tissues examined
• highest levels in heart, placenta, & skeletal muscle
• moderate levels in lung & liver
• low levels in brain, kidney, & pancreas

Pathology

defects in RRAS2 may be a cause of ovarian tumors

More general terms

• ras subfamily protein

Database

• UniProt: http://www.uniprot.org/uniprot/P62070.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=22800
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:22800
• OMIM: https://mirror.omim.org/entry/600098