protein tyrosine phosphatase 8/22, non-receptor type; PTPN8/22; hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; lymphoid phosphatase; LyP (PTPN22, PTPN8)

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Function

seems to act on Cbl
may play a role in regulating function of Cbl & its associated protein kinases
negative regulator of T-cell receptor signaling by direct dephosphorylation of the Src family kinases LCK & FYN, ITAMs of the TCRz/CD3 complex, ZAP70, VAV, VCP
seems to dephosphorylate CBL
dephosphorylates LCK at its activating Y394
dephosphorylates ZAP70 at its activating Y493
dephosphorylates the immune system activator SKAP2
positively regulates toll-like receptor-induced interferon type-1 production
promotes host antiviral responses mediated by interferon type-1 interferon (putative)
egulates NOD2-induced pro-inflammatory cytokine secretion & autophagy
down-regulated by phosphorylation
phosphorylation on Ser-35 by PKC/PRKCD abrogates its ability to dephosphorylate & inactivate the SRC family kinases
interacts with CSK
interacts with LPXN (putative)
interacts with TRAF3 (via MATH domain); the interaction promotes TRAF3 polyubiquitination

belongs to the protein-tyrosine phosphatase family non-receptor class 4 subfamily
contains 1 tyrosine-protein phosphatase domain

named isoforms=6
at least one isoform due to intron retention
at least one isoform lacks most of the phosphatase domain & functions as a dominant negative isoform

expressed in bone marrow, B & T-cells, NK cells, monocytes, dendritic cells & neutrophils
isoforms 1 & 4 predominantly expressed in lymphoid tissues & cells
isoform 1 is expressed in thymocytes & both mature B-cells & T-cells
expression induced by muramyl-dipeptide & lipopolysaccharide

susceptibility to systemic lupus erythematosus is associated with variations in PTPN22
susceptibility to diabetes mellitus type 1 is associated with variations in PTPN22
susceptibility to rheumatoid arthritis is associated with variations in PTPN22
susceptibility to vitiligo is associated with variations in PTPN22