salsalate (Salflex, Disalcid, sasapyrine)
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Introduction
Tradenames: Salflex, Disalcid.
Indications
- temporary relief from minor aches & pains, fever & inflammation
- rheumatoid arthritis
- osteoarthritis
- lowers hemoglobin A1c in diabetes mellitus type-2[4]
Contraindications
Dosage
Tabs: 500, 750 mg.
Pharmacokinetics
- bioavailability is dependent upon dose form
- drug eliminated primarily by the kidneys
elimination via kidney
1/2life = 1 hours
Adverse effects
- common (> 10%)
- less common (1-10%)
- uncommon (< 1%)
- other
- may be associated with Reye's syndrome when used by children or teenagers with influenza or chicken pox
- does not appear to affect platelet aggregation
Drug interactions
- corticosteroids
- increase clearance of salicylates
- may increase nephrotoxicity
- ACE inhibitors: decreased antihypertensive effect
- warfarin: minimal prolonged bleeding time
- salsalate increases methotrexate levels & possible toxicity
- drug interaction(s) of direct oral anticoagulants (DOAC) with NSAIDs
- drug interaction(s) of cholinesterase inhibitors with NSAIDs
- drug interaction(s) of lithium carbonate with NSAIDs
- drug interaction(s) of beta-adrenergic receptor antagonists with salicylate
- drug interaction(s) of salicylates with sulfonylureas
- drug interaction(s) of NSAIDs with oral contraceptive
- drug interaction(s) of NSAIDs with SSRIs
- drug interaction(s) of NSAIDs with antidepressants
- drug interaction(s) of aspirin with NSAIDs
- drug interaction(s) of apixaban with NSAIDs
- drug interaction(s) of warfarin with NSAIDs
- drug interaction(s) of NSAIDs with beta blockers
- drug interaction(s) of NSAIDs with ARBs
- drug interaction(s) of NSAIDs with aldosterone antagonis
- drug interaction(s) of NSAIDs with glucocorticoid
- drug interaction(s) of NSAIDs, diuretics & angiotensin II receptor antagonists
- drug interaction(s) of NSAIDs, diuretics & ACE inhibitors
- drug interaction(s) of NSAIDs with ACE inhibitors
- drug interaction(s) of NSAIDs & antihypertensives
- drug interaction(s) of NSAIDs & loop diuretics
- drug interaction(s) of NSAIDs & aspirin
Mechanism of action
- analgesic, antipyretic, anti-inflammatory & anti-rheumatic effects
More general terms
References
- ↑ The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- ↑ Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
- ↑ Kaiser Permanente Northern California Regional Drug Formulary, 1998
- ↑ 4.0 4.1 Goldfine AB et al. The effects of salsalate on glycemic control in patients with type 2 diabetes: A randomized trial. Ann Intern Med 2010 Mar 16; 152:346. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20231565
- ↑ 5.0 5.1 NEJM Knowledge+ Allergy/Immunology