pim1 proto-oncogene protein

^[1]^[2]^[3]^[4]^[5]

Function

Pim-1 interacts with & may play a role in promoting complex formation between NuMA, HP1-beta, dynein & dynactin which is necessary for mitosis
during prometaphase, pim-1 interacts with NuMA & centromere associated protein HP1
Pim-1 phosphorylates NuMA^[4].
Hsp90-alpha & hsp90-beta interact with pim-1 & affect its stablization & function.
Pim-1 phosphorylation of cdc25A upregulates phosphatase activity
Pim-1 is regulated by various cytokines including GM-CSF, G-CSF, interleukin-3, interferon-alpha & interleukin-6

during the cell cycle, pim-1 moves from the nucleus & cytoplasm in interphase to the spindle poles during mitosis
in late metaphase/early anaphase pim-1 associates with the spindle & moves to the cleavage furrow during telophase

overexpressed in a subset of hematolymphoid malignancies
also expressed in high levels in malignant prostate tissue, but absent in metastatic tissue

there is a pim1 gene in Saccharomyces pombe that is a homolog of RCC1
the product of the yeast gene is a serine/threonine kinase implicated in coupling S -> M phase transition in the cell cycle

↑ te Riele H, Maandag ER, Clarke A, Hooper M, Berns A. Consecutive inactivation of both alleles of the pim-1 proto-oncogene by homologous recombination in embryonic stem cells. Nature 348:649 1990 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2250720
↑ Padma R & Nagarajan L The human PIM-1 gene product is a protein serine kinase. Cancer Res 51:2486 1991 PMID: https://www.ncbi.nlm.nih.gov/pubmed/1826633
↑ Journal Watch 21(20):162, 2001 Dhanasekaran SM et al Delineation of prognostic biomarkers in prostate cancer. Nature 412:822, 2001 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11518967
↑ ^4.0 ^4.1 Bhattacharya N et al. Pim-1 associates with protein complexes necessary for mitosis. Chromosoma 111:80-95, 2002 PMID: https://www.ncbi.nlm.nih.gov/pubmed/12111331
↑ Mizuno K et al. Regulation of Pim-1 by Hsp90. Biochemical & Biophysical Research Communications 281:663-669, 2001 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11237709