biotherapy (immunotherapy)

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Introduction

Use of the immune system directly or indirectly to treat disease, especially cancer. May include administration of biologic agents such as:

or procedures such as

Notes

More general terms

More specific terms

Additional terms

References

  1. Biological Therapies: Using the Immune System To Treat Cancer http://cis.nci.nih.gov/fact/7_2.htm
  2. 2.0 2.1 Kottke T et al. Broad antigenic coverage induced by vaccination with virus-based cDNA libraries cures established tumors. Nat Med 2011 Jul; 17:854. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21685898
    Alvarez-Breckenridge C and Chiocca EA. A viral strategy to ambush tumors. Nat Med 2011 Jul; 17:784 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21738155
  3. 3.0 3.1 Couzin-Frankel J Cancer Immunotherapy Science 2013: Vol. 342 no. 6165 pp. 1432-1433 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24357284 <Internet> http://www.sciencemag.org/content/342/6165/1432.full
  4. 4.0 4.1 Elia J Treatment Approach Expands Population of Tumor-Infiltrating Lymphocytes. Physician's First Watch, May 12, 2014 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org
    Tran E et al Cancer Immunotherapy Based on Mutation-Specific CD4+ T Cells in a Patient with Epithelial Cancer. Science 9 May 2014: Vol. 344 no. 6184 pp. 641-645 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24812403 <Internet> http://www.sciencemag.org/content/344/6184/641.abstract
  5. Komaroff AL Immunotherapy Against Multiple Opportunistic Viruses in Immunocompromised Patients NEJM Journal Watch. July 10, 2014 Massachusetts Medical Society (subscription needed) http://www.jwatch.org
    Papadopoulou A at al. Activity of broad-spectrum T cells as treatment for AdV, EBV, CMV, BKV, and HHV6 infections after HSCT. Sci Transl Med 2014 Jun 25; 6:242ra83 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24964991 <Internet> http://stm.sciencemag.org/content/6/242/242ra83
  6. Komaroff AL Immunotherapy to Fight Cancer Begins to Work. NEJM Journal Watch. June 16, 2015 Massachusetts Medical Society (subscription needed) http://www.jwatch.org
    Rosenberg SA and Restifo NP. Adoptive cell transfer as personalized immunotherapy for human cancer. Science 2015 Apr 3; 348:62 PMID: https://www.ncbi.nlm.nih.gov/pubmed/25838374
    June CH et al. Adoptive cellular therapy: A race to the finish line. Sci Transl Med 2015 Mar 25; 7:280ps7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/25810311
    Sharma P and Allison JP. The future of immune checkpoint therapy. Science 2015 Apr 3; 348:56. PMID: https://www.ncbi.nlm.nih.gov/pubmed/25838373
    Schumacher TN and Schreiber RD. Neoantigens in cancer immunotherapy. Science 2015 Apr 3; 348:69. PMID: https://www.ncbi.nlm.nih.gov/pubmed/25838375
    Mueller KL. Cancer immunology and immunotherapy. Realizing the promise. Science 2015 Apr 3; 348:54. PMID: https://www.ncbi.nlm.nih.gov/pubmed/25838372
    Joyce JA and Fearon DT. T cell exclusion, immune privilege, and the tumor microenvironment. Science 2015 Apr 3; 348:74 PMID: https://www.ncbi.nlm.nih.gov/pubmed/25838376
    Wolchok JD and Chan TA. Cancer: Antitumour immunity gets a boost. Nature 2014 Nov 27; 515:496. PMID: https://www.ncbi.nlm.nih.gov/pubmed/25428495
    Brahmer J et al. Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. N Engl J Med 2015 May 31 PMID: https://www.ncbi.nlm.nih.gov/pubmed/26028407
    Larkin J et al. Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N Engl J Med 2015 May 31; PMID: https://www.ncbi.nlm.nih.gov/pubmed/26027431
    Le DT et al. PD-1 blockade in tumors with mismatch-repair deficiency. N Engl J Med 2015 May 30 PMID: https://www.ncbi.nlm.nih.gov/pubmed/26028255
    Lonial S et al. Elotuzumab therapy for relapsed or refractory multiple myeloma. N Engl J Med 2015 Jun 2; PMID: https://www.ncbi.nlm.nih.gov/pubmed/26035255
  7. Grady D Harnessing the Immnune System to Fight Cancer. New York Times. July 30, 2016 http://www.nytimes.com/2016/07/31/health/harnessing-the-immune-system-to-fight-cancer.html