interferon-gamma 1B

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Introduction

Tradename: Actimmune.

Indications

Contraindications

Caution:

Dosage

  • < 0.5 m2 body area: 1.5 ug/kg SC 3 times/week
  • > 0.5 m2 body area: 50 ug/m2 (1.5 million units/m2) SC 3 times/week
  • acetaminophen may be used to prevent fever & headache

Injection: 100 ug (3 million units) (single use only)

Pharmacokinetics

Monitor

Adverse effects

Drug interactions

Mechanism of action

More general terms

Additional terms

References

  1. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  2. 2.0 2.1 Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
  3. Department of Veterans Affairs, VA National Formulary
  4. 4.0 4.1 FDA Medwatch http://www.fda.gov/medwatch/safety/2007/safety07.htm#Actimmune
    King TE et al Effect of interferon gamma-1b on survival in patients with idiopathic pulmonary fibrosis (INSPIRE): a multicentre, randomised, placebo-controlled trial Lancet, Early Online Publication, 30 June 2009 doi:10.1016/S0140-6736(09)60551-1
  5. 5.0 5.1 Deprecated Reference