anemia of chronic inflammation

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Introduction

Patients with chronic systemic inflammatory disorders for more than a month usually develop mild to moderate anemia.

Etiology

Pathology

Laboratory

Management

More general terms

Additional terms

References

  1. Saunders Manual of Medical Practice, Rakel (ed), WB Saunders, Philadelphia, 1996, pg 573
  2. Harrison's Principles of Internal Medicine, 13th ed. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1994, pg 1732
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Medical Knowledge Self Assessment Program (MKSAP) 11, 15, 16, 17, 18, 19. American College of Physicians, Philadelphia 1998, 2009, 2012, 2015, 2018, 2022.
  4. 4.0 4.1 Perlstein TS et al. Prevalence of 25-hydroxyvitamin D deficiency in subgroups of elderly persons with anemia: Association with anemia of inflammation. Blood 2011 Mar 10; 117:2800. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21239700
  5. Cheng PP, Jiao XY, Wang XH, Lin JH, Cai YM. Hepcidin expression in anemia of chronic disease and concomitant iron-deficiency anemia. Clin Exp Med. 2011 Mar;11(1):33-42 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20499129
  6. 6.0 6.1 Ferrucci L, Semba RD, Guralnik JM et al Proinflammatory state, hepcidin, and anemia in older persons. Blood. 2010 May 6;115(18):3810-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20081092
  7. Wang CY, Babitt JL. Hepcidin regulation in the anemia of inflammation. Curr Opin Hematol. 2016 May;23(3):189-97. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/26886082 Free PMC Article
  8. Ganz T Anemia of Inflammation. N Engl J Med 2019; 381:1148-1157. Sept 19, 2019 PMID: https://www.ncbi.nlm.nih.gov/pubmed/31532961 https://www.nejm.org/doi/full/10.1056/NEJMra1804281
    Rothaus C Anemia of Inflammation NEJM Resident 360. Sept 18, 2019 https://resident360.nejm.org/clinical-pearls/anemia-of-inflammation
  9. ARUP Consult: Anemia of Chronic Disease - Anemia of Inflammation The Physician's Guide to Laboratory Test Selection & Interpretation https://www.arupconsult.com/content/anemia-chronic-disease-anemia-inflammation
    Iron Deficiency Anemia and Anemia of Chronic Disease/Anemia of Inflammation Testing Algorithm https://arupconsult.com/algorithm/iron-deficiency-anemia-and-anemia-chronic-diseaseanemia-inflammation-testing-algorithm
  10. Weiss G, Ganz T, Goodnough LT. Anemia of inflammation. Blood. 2019;133:40-50. PMID: https://www.ncbi.nlm.nih.gov/pubmed/30401705

Patient information

anemia of chronic inflammation patient information