solute carrier family 40 member 1 (SLC40A1, SLC11A3, ferroportin-1, iron-regulated transporter 1, proton-coupled divalent metal ion transporter, FPN1, IREG1, MSTP079)

Function

• iron export from duodenal epithelial cells (putative)
• transfer of iron between maternal & fetal circulation (putative)
• mediates iron efflux in the presence of a ferroxidase (hephaestin &/or ceruloplasmin)
• regulated (inhibited) by hepcidin)
  • hepcidin binds to ferroprotein causing internalization & subsequent degradation by the proteasome
  • this results in retention of iron within the cell (enterocyte, hepatocyte, macrophage) & reduction of plasma iron

Compartment

• localized to basolateral membrane of polarized epithelial cells

Expression

• expressed in placenta, intestine, muscle & spleen
• expressed in duodenal enterocytes, hepatocytes & macrophages of the reticuloendothelial system

Pathology

• defects in SLC40A1 are the cause of hemochromatosis type 4

More general terms

• transmembrane 10e protein
• solute carrier family 40 (SLC40, SLC40A)
• solute carrier family 11 (SLC11, SLC11A)
• glycoprotein

Additional terms

• hemochromatosis
• hepcidin antimicrobial peptide; liver-expressed antimicrobial peptide; LEAP-1; putative liver tumor regressor; PLTR [Contains: Hepcidin-25 (Hepc25); Hepcidin-20 (Hepc20)] (HAMP, HEPC, LEAP1, UNQ487/PRO1003)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3006
• OMIM: https://mirror.omim.org/entry/604653
• OMIM: https://mirror.omim.org/entry/606069
• UniProt: http://www.uniprot.org/uniprot/Q9NP59.html