hepcidin antimicrobial peptide; liver-expressed antimicrobial peptide; LEAP-1; putative liver tumor regressor; PLTR [Contains: Hepcidin-25 (Hepc25); Hepcidin-20 (Hepc20)] (HAMP, HEPC, LEAP1, UNQ487/PRO1003)

From Aaushi
Jump to navigation Jump to search

Function

Compartment

secreted, secreted into the urine

Expression

Pathology

Pharmacology

Laboratory

More general terms

References

  1. UniProt http://www.uniprot.org/uniprot/P81172.html
  2. GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=HAMP
  3. Medical Knowledge Self Assessment Program (MKSAP) 16, American College of Physicians, Philadelphia 2012
  4. Babitt JL, Lin HY Molecular mechanisms of hepcidin regulation: implications for the anemia of CKD. Am J Kidney Dis. 2010 Apr;55(4):726-41 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20189278
  5. Nemeth E, Ganz T. The role of hepcidin in iron metabolism. Acta Haematol. 2009;122(2-3):78-86 PMID: https://www.ncbi.nlm.nih.gov/pubmed/19907144
    Nemeth E, Tuttle MS, Powelson J, Vaughn MB et al Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004 Dec 17;306(5704):2090-3. Epub 2004 Oct 28. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15514116
  6. 6.0 6.1 Ferrucci L, Semba RD, Guralnik JM et al Proinflammatory state, hepcidin, and anemia in older persons. Blood. 2010 May 6;115(18):3810-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20081092
  7. 7.0 7.1 Sun CC, Vaja V, Babitt JL, Lin HY. Targeting the hepcidin-ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of inflammation. Am J Hematol. 2012 Apr;87(4):392-400. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22290531

Database