hepcidin in serum/plasma
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Reference interval
- nmoles/L
Clinical significance
- decreases in iron-deficiency
- binding to & induces degradation of ferroportin, which exports iron from cells
- in iron deficiency, transcription of hepcidin is suppressed
- this adaptive mechanism facilitates absorption of iron & release of iron from body stores
Decreases
- dapagliflozin may decrease plasma hepcidin in patients with diabetes mellitus type 2[3]
More general terms
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Additional terms
References
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 16, American College of Physicians, Philadelphia 2012
- ↑ Rothaus C Iron-Deficiency Anemia Now@NEJM http://blogs.nejm.org/now/index.php/iron-deficiency-anemia/2015/05/08/
- ↑ 3.0 3.1 Monaco K Dapagliflozin Tied to Drop in Hepcidin Levels. Decrease may boost hematocrit and hemoglobin after SGLT-2 inhibitor therapy. MedPage Today. May 20, 2018 https://www.medpagetoday.com/meetingcoverage/aace/72989
Ghanim H, et al Dapagliflozin Suppresses Plasma Hepcidin Concentrations. American Association of Clinical Endocrinologists (AACE) 2018; Abstract 228