protein CYR61; CCN family member 1; cysteine-rich angiogenic inducer 61; insulin-like growth factor-binding protein 10; IBP-10; IGF-binding protein 10; IGFBP-10; protein GIG1 (CYR61, CCN1, GIG1, IGFBP10)

Function

• promotes cell proliferation, chemotaxis, angiogenesis & cell adhesion
• appears to play a role in wound healing by up-regulating, in skin fibroblasts, expression of a number of genes involved in angiogenesis, inflammation & matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 & integrins, integrin alpha-3 & integrin alpha-5
• CYR61-mediated gene regulation is dependent on heparin-binding
• down-regulates expression of collagen type-1 subunits COL1A1 & COL1A2
• promotes cell adhesion & adhesive signaling through integrin alpha-6/beta-1
• promotes cell migration through integrin alpha-v/beta-5
• promotes cell proliferation through integrin alpha-v/beta-3
• interaction with integrins is heparin- & cell-type-dependent & promotes cell adhesion
• in skin fibroblasts, binds ITGA6/ITGB1
• in endothelial cells, binds ITGAV/ITGB3
• in platelets, binds ITGA2B/ITGB3
• in vitro, binds ITGAV/ITGB5

Structure

• belongs to the CCN family
• contains 1 CTCK (C-terminal cystine knot-like) domain
• contains 1 IGFBP N-terminal domain
• contains 1 TSP type-1 domain
• contains 1 VWFC domain

Compartment

secreted

More general terms

• secreted protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3491
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3491
• OMIM: https://mirror.omim.org/entry/602369
• UniProt: http://www.uniprot.org/uniprot/O00622.html