DCN1-like protein 1; DCUN1 domain-containing protein 1; defective in cullin neddylation protein 1-like protein 1; squamous cell carcinoma-related oncogene (DCUN1D1, DCUN1L1, RP42, SCCRO)

Function

• neddylation of cullins in E3 ubiquitin ligase complexes (SCF-type)
• component of an E3 ubiquitin ligase complex for neddylation
• recruits the NEDD8-charged E2 enzyme to the cullin component
• role in release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly & activity
• interacts (via the C-terminus 50 AA) with CUL1, CUL2, CUL3, CUL4 & CUL5
• binds neddylated CUL1
• interacts (via the C-terminus 50 AA) directly with RBX1
• interacts preferentially with UBE2M-NEDD8 thioester (via N-terminus 1-26 AA) than with free UBE2M
• interacts with CAND1 when in complex with CUL1-RBX1

Structure

• contains 1 DCUN1 domain
• contains 1 UBA-like domain

Expression

• expressed in pancreas, kidney, placenta, brain, heart > liver, skeletal muscle, lung

Pathology

• acts also as an oncogene facilitating malignant transformation & carcinogenic progression (putative)
• defects in DCUN1D1 may be a cause of squamous cell carcinomas
• overexpressed in malignant tissues of squamous cell carcinoma of the tongue, thyroid tumors,
  • expression correlates with invasive progression in bronchioloalveolar carcinoma
• not overexpressed in aggressive adrenocortical carcinomas

More general terms

• DCN1-like protein (defective in cullin neddylation protein 1-like protein)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54165
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:54165
• OMIM: https://mirror.omim.org/entry/605905
• UniProt: http://www.uniprot.org/uniprot/Q96GG9.html