risk factors & protective factors for vascular dementia
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Introduction
- ischemic stroke(s)
- multi-infarct dementia
- strategic infarcts
- small vessel disorders
- embolic stroke
- hemorrhagic stroke(s)
- atherosclerosis, coronary artery disease[2][3]
- high blood pressure
- systolic blood pressure variation[4]
- cerebral amyloid angiopathy
- primary CNS angiitis
- diabetes
- obesity
- hypercholesterolemia
- cigarette smoking
- ultraprocessed foods[6]
- osmotic laxative use & multiple different laxatives use associated with increased risk for all-cause dementia (RR=1.64) & vascular dementia (RR=1.97)[10]
- the most consistent associations across 13 years are an
* vascular risk factors when present in midlife are associated with increased risk of vascular dementia in later life[5]
Protective factors
More general terms
Additional terms
References
- ↑ Kristi Wagner Steh, West Los Angeles VA, GRECC, Dec 2003
Cummings JL, The Neuropsychiatry of Alzheimer's Disease and Related Dementias, Martine Dunitz LTD, Taylor & Francis Group, London (2003)
Mendez MF & Cummings JL, Dementia: A Clinical Approach, Butterworth & Heinemann, Philadelphia (2003) - ↑ 2.0 2.1 van Oijen M et al, Atherosclerosis and risk for dementia. Ann Neurol 2007, 61:403 PMID: https://www.ncbi.nlm.nih.gov/pubmed/17328068
- ↑ 3.0 3.1 Selnes OA et al, Cognition 6 years after surgical or medical therapy for coronary artery disease. Ann Neurol 2008, 63:581 PMID: https://www.ncbi.nlm.nih.gov/pubmed/18481292
Yaffe K and Covinsky KE Coronary bypass surgery and long-term cognitive decline. Ann Neurol 2008, 63:547 PMID: https://www.ncbi.nlm.nih.gov/pubmed/18481289 - ↑ 4.0 4.1 Oishi E, Ohara T, Sakata S et al Day-to-day blood pressure variability and risk of dementia in a general Japanese elderly population: the hisayama study. Circulation 2017 PMID: https://www.ncbi.nlm.nih.gov/pubmed/28784822
Merkler A et al Rollercoaster blood pressure, an Alzheimer disease risk factor? Circulation. 2017 Aug 8;136(6):516-525. PMID: https://www.ncbi.nlm.nih.gov/pubmed/28784823 - ↑ 5.0 5.1 Gottesman RF, Albert MS, Alonso A et al Associations Between Midlife Vascular Risk Factors and 25-Year Incident Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort JAMA Neurol. Published online August 7, 2017. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28783817 <Internet> http://jamanetwork.com/journals/jamaneurology/article-abstract/2646624
- ↑ 6.0 6.1 Li H et al. Association of ultraprocessed food consumption with risk of dementia: A prospective cohort study. Neurology 2022 Jul 27; 99:e1056. PMID: https://www.ncbi.nlm.nih.gov/pubmed/35896436 https://n.neurology.org/content/99/10/e1056
- ↑ 7.0 7.1 George J Earlier Health Conditions Tied to Subsequent Dementia. Alzheimer's disease, vascular dementia links are time-dependent. MedPage Today January 5, 2023 https://www.medpagetoday.com/neurology/dementia/102521
Beason-Held LL, Kerley CI, Chaganti S et al Health Conditions Associated with Alzheimer's Disease and Vascular Dementia. Ann Neurol. 2022. Dec 26 PMID: https://www.ncbi.nlm.nih.gov/pubmed/36571386 https://onlinelibrary.wiley.com/doi/10.1002/ana.26584 - ↑ 8.0 8.1 Friberg L, Rosenqvist M. Less dementia with oral anticoagulation in atrial fibrillation. European Heart Journal. Oct 24, 2017 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29077849 https://academic.oup.com/eurheartj/article-lookup/doi/10.1093/eurheartj/ehx579
Styles S Cutting Dementia Risk in Atrial Fibrillation: Does Rhythm Control Strategy Matter? Medscape. April 29, 2022 https://www.medscape.com/viewarticle/972967 - ↑ 9.0 9.1 Purandare N et al. Association of cerebral emboli with accelerated cognitive deterioration in Alzheimer's disease and vascular dementia. Am J Psychiatry 2012 Mar 1; 169:300. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22193532
Doraiswamy PM. Silent cerebrovascular events and Alzheimer's disease: An overlooked opportunity for prevention? Am J Psychiatry 2012 Mar 1; 169:251. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22407112 - ↑ 10.0 10.1 Yang Z, Wei C, Li X et al Association Between Regular Laxative Use and Incident Dementia in UK Biobank Participants. Neurology. 2023, Feb 22 PMID: https://www.ncbi.nlm.nih.gov/pubmed/36813729 https://n.neurology.org/content/early/2023/02/22/WNL.0000000000207081