Sorbin & SH3 domain-containing protein 2; Arg/Abl-interacting protein 2; ArgBP2; Sorbin (SORBS2, ARGBP2, KIAA0777)
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Function
- adapter protein
- role in the assembling of signaling complexes, being a link between ABL kinases & actin cytoskeleton
- can form complex with ABL1 & CBL, thus promoting ubiquitination & degradation of ABL1 or with AKT1 & PAK1, thus mediating AKT1-mediated activation of PAK1
- isoform 6 increases water & Na+ absorption in the intestine & gall-bladder
- interacts with ABL, CBL, DNM1, DNM2, FLOT1, MLLT4/afadin, PTK2B/PYK2, SAPAP, SPTAN1, SYNJ1, SYNJ2, VCL/vinculin, & WASF (putative)
- interacts with ABL1/c-Abl, ABL2/v-Abl/Arg, ACTN, AKT1, CBL, PALLD & PAK1
- ubiquitinated by CBL
Structure
- contains 3 SH3 domains
- contains 1 SoHo domain
- contains alanine amide at position 153
Compartment
- cytoplasm, perinuclear region
- found at the Z-disk sarcomeres, stress fibers, dense bodies & focal adhesion
Alternative splicing
named isoforms=6
Expression
- abundantly expressed in heart in cardiac muscle cells, located in the Z-disks of sarcomere
- also found, but to a lower extent, in small & large intestine, pancreas, thymus, colon, spleen, prostate, testis, brain, ovary & epithelial cells