synaptojanin-2; synaptic inositol-1,4,5-trisphosphate 5-phosphatase 2 (SYNJ2, KIAA0348)

Function

• inositol 5-phosphatase
• may be involved in distinct membrane trafficking & signal transduction pathways
• may mediate the inhibitory effect of Rac1 on endocytosis
• binds to GRB2
• isoform 2A binds to SYNJ2BP/OMP25
• isoform 2B2 C-terminal proline-rich region binds to a variety of SH3 domain-containing proteins including SH3GL1, SH3GL2, SH3GL3 & GRB2

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate

Structure

• belongs to the synaptojanin family
• in the central section; belongs to the inositol-1,4,5-trisphosphate 5-phosphatase family
• contains 1 RRM domain (RNA recognition motif)
• contains 1 SAC domain

Compartment

• membrane (putative)
• predominantly associated with the particulate fractions (putative)

Alternative splicing

• named isoforms=3; 2B2, 2B1, 2A
• additional isoforms seem to exist

More general terms

• phosphomonoesterase
• RNA-binding protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8871
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8871
• OMIM: https://mirror.omim.org/entry/609410
• UniProt: http://www.uniprot.org/uniprot/O15056.html