flotillin-1 (FLOT1)

Introduction

Integral/structural component of lipid rafts.

Function

• may act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles
• heterooligomeric complex of flotillin-1 & flotillin-2 & caveolin-1 & caveolin-2 (putative)

Structure

• belongs to the band 7/mec-2 family, Flotillin subfamily

Compartment

• cell membrane; peripheral membrane protein
• membrane, caveola; peripheral membrane protein
• melanosome
• membrane-associated protein of caveolae
• identified by mass spectrometry in melanosome fractions from stage I to stage IV

More general terms

• flotillin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10211
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10211
• OMIM: https://mirror.omim.org/entry/606998
• UniProt: http://www.uniprot.org/uniprot/O75955.html