flotillin-2; epidermal surface antigen; ESA; membrane component chromosome 17 surface marker 1 (FLOT2, ESA1, M17S1)

Function

• may act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles
• may be involved in epidermal cell adhesion & epidermal structure & function
• heterooligomeric complex of flotillin-1 & flotillin-2 & caveolin-1 & caveolin-2 (putative)

Structure

• belongs to the band 7/mec-2 family, Flotillin subfamily

Compartment

• cell membrane; peripheral membrane protein membrane
• caveola; peripheral membrane protein
• membrane- associated protein of caveolae

Expression

• in skin, expressed in epidermis & epidermal appendages but not in dermis
• expressed in all layers of the epidermis except the basal layer
• in hair follicles, expressed in the suprabasal layer but not the basal layer
• also expressed in melanoma & carcinoma cell lines, fibroblasts & foreskin melanocytes

More general terms

• flotillin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2319
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2319
• OMIM: https://mirror.omim.org/entry/131560
• UniProt: http://www.uniprot.org/uniprot/Q14254.html