common prescription drugs associated with insomnia

Etiology

Antihypertensives:

• clonidine
• beta-blockers
  • propranolol
  • atenolol
  • pindolol
• methyldopa
• reserpine

Anticholinergic agents

• ipratropium (Atrovent)

Analeptics

• methylphenidate

Endocrine agents

• oral contraceptives
• thyroxine
• glucocorticoids
• progesterone

Sympathomimetic amines

• bronchodilators
  • terbutaline
  • albuterol
  • salmeterol
  • metaproterenol
• theophylline
• decongestants
  • phenylpropanolamine
  • pseudoephedrine

Antineoplastic agents

• medroxyprogesterone
• leuprolide
• goserelin
• pentostatin
• daunorubicin
• interferon-alpha

Miscellaneous agents

• phenytoin
• nicotine
• levodopa
• quinidine
• caffeine*

* many over the counter products contain caffeine, including aspirin

• cough/cold preparations
• beverages (colas ..)

Management

• melatonin 2.5 mg nightly decreases sleep latency & increases sleep duration in patients taking beta-blockers

More general terms

• drug adverse effect(s)