leuprolide; leuprorelin (Lupron, Eligard)

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Introduction

Tradename: Lupron.

Indications

Contraindications

pregnancy category = x

safety in lactation = -

Dosage

Do NOT use needles smaller than 22 guage when administering depot form. Use only diluent provided.

Store unopened vials in refrigerator.

Vial in use can be kept at room temperature for months.

Reconstituted suspension stable for 24 hours

Injection: 5 mg/mL (2.8 mL) Suspension, Depot (1 month):

Adverse effects

Test interactions

  • interferes with pituitary gonadoropic & gonadal function test during & up to 4-8 weeks after therapy

Mechanism of action

More general terms

More specific terms

Component of

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  3. DrugDex Drug Evaluation, vol 105, 2000
  4. 4.0 4.1 Deprecated Reference
  5. Kaunitz AM Nocturnal Hot Flashes, Sleep Disturbances, and Worsening Mood: The Perfect Storm? NEJM Journal Watch. Oct 11, 2016 Massachusetts Medical Society (subscription needed) http://www.jwatch.org
  6. 6.0 6.1 6.2 Geriatric Review Syllabus, 10th edition (GRS10) Harper GM, Lyons WL, Potter JF (eds) American Geriatrics Society, 2019

Database