induced pluripotent stem cell (iPS)

From Aaushi
Jump to navigation Jump to search

Introduction

Cells, similar to embryonic stem cells, derived from differentiated skin cells (keratinocytes), 1st in mice, then in humans

Clinical significance

Procedure

Complications

  • technique that requires introduction of genes into adult cells can induce tumors if they insert into the wrong place
  • transfection with mRNA rather than DNA may minimize risk of inducing tumors[5]
  • iPS cells often contain genetic modifications (e.g., point mutations, copy number variations) & epigenetic modifications that could render iPS cells cancerous or cause them to self-destruct after continued division[6]
  • screening protocols may be necessary[6]
  • more immunogenic & more likely than embryonic stem cells to induce rejection[7]

Comparative biology

Notes

More general terms

Additional terms

References

  1. Takahashi K et al, Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007, Nov 20, 131:861 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/18035408 <Internet> http://dximages.cell.com/images/images/cell/ieps/3661.pdf Yu J et al, Induced pluripotent stem cells derived from human somatic cells. Science 2007, Nov 20 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/18029452 <Internet> http://dx.doi.org/10.1126/science.1151526
  2. Hanna J et al, Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science 2007, Dec 6 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/18063756 <Internet> http://dx.doi.org/10.1126/science.1152092
  3. Wernig M et al, Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc Natl Acad Sci USA 2008, 105:5856 PMID: https://www.ncbi.nlm.nih.gov/pubmed/18391196
  4. 4.0 4.1 Dimos JT et al. Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science 2008 Jul 31; [e-pub ahead of print] <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/18669821 <Internet> http://dx.doi.org/10.1126/science.1158799
    Park I-H et al. Disease-specific induced pluripotent stem cells. Cell 2008 Aug 7; [e-pub ahead of print] <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/18691744 <Internet> http://dx.doi.org/10.1016/j.cell.2008.07.041
  5. 5.0 5.1 5.2 Warren L et al. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell 2010 Sep 30 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20888316 Journal Watch, Massachessetts Medical Society, Nov 3, 2010 http://www.jwatch.org
  6. 6.0 6.1 6.2 Hussein SM et al. Copy number variation and selection during reprogramming to pluripotency. Nature 2011 Mar 3; 471:58. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21368824
    Gore A et al. Somatic coding mutations in human induced pluripotent stem cells. Nature 2011 Mar 3; 471:63. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21368825
    Lister R et al. Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature 2011 Mar 3; 471:68. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21289626
    Pera MF. Stem cells: The dark side of induced pluripotency. Nature 2011 Mar 3; 471:46 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21368819
  7. 7.0 7.1 Zhao T et al. Immunogenicity of induced pluripotent stem cells. Nature 2011 May 13; 474:212. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21572395
    Mummery C. Induced pluripotent stem cells - A cautionary note. N Engl J Med 2011 Jun 2; 364:2160. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21631331
  8. 8.0 8.1 Pang ZP et al. Induction of human neuronal cells by defined transcription factors. Nature 2011 Aug 11; 476:220 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21617644
    Caiazzo M et al. Direct generation of functional dopaminergic neurons from mouse and human fibroblasts. Nature 2011 Aug 11; 476:224. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21725324
    Yoo AS et al. MicroRNA-mediated conversion of human fibroblasts to neurons. Nature 2011 Aug 11; 476:228 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21753754
    Sendtner M. Bespoke cells for the human brain. Nature 2011 Aug 11; 476:158 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21833079
  9. 9.0 9.1 Israel MA et al. Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature 2012 Jan 25; PMID: https://www.ncbi.nlm.nih.gov/pubmed/22278060
  10. 10.0 10.1 Rais Y et al. Deterministic direct reprogramming of somatic cells to pluripotency. Nature 2013 Oct 3; 502:65. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24048479 <Internet> http://www.nature.com/nature/journal/v502/n7469/full/nature12587.html
    Loh KM and Lim B.Stem cells: Close encounters with full potential. Nature 2013 Oct 3; 502:41 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24048472 <Internet> http://www.nature.com/nature/journal/v502/n7469/full/nature12561.html
  11. 11.0 11.1 11.2 11.3 11.4 Obokata H et al. Stimulus-triggered fate conversion of somatic cells into pluripotency. Nature 2014 Jan 30; 505:641 PMID: https://www.ncbi.nlm.nih.gov/pubmed/24476887
    Obokata H et al. Bidirectional developmental potential in reprogrammed cells with acquired pluripotency. Nature 2014 Jan 30; 505:676 PMID: https://www.ncbi.nlm.nih.gov/pubmed/24476891
    Cyranoski D Mismatch alleged in acid-bath stem-cell experiment. Cell lines linked to blockbuster papers came from different mouse strain to that claimed, study suggests. Nature. March 27, 2014 http://www.nature.com/news/mismatch-alleged-in-acid-bath-stem-cell-experiment-1.14946
    Nature editorial STAP retracted. Two retractions highlight long-standing issues of trust and sloppiness that must be addressed. Nature, July 2, 2014 http://www.nature.com/news/stap-retracted-1.15488
  12. Kikuchi T, Morizane A, Doi D et al. Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model. Nature 2017 Aug 31; 548:592. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28858313 <Internet> http://www.nature.com/nature/journal/v548/n7669/full/nature23664.html