Krueppel-like factor 4; epithelial zinc finger protein EZF; Gut-enriched krueppel-like factor (KLF4 EZF GKLF)

Function

• transcription factor
  • can act both as activator & as repressor
• binds the 5'-CACCC-3' core sequence
• binds to the promoter region of its own gene & can activate its own transcription
• regulates expression of key transcription factors during embryonic development
• role in maintaining embryonic stem cells, & in preventing their differentiation
• required for establishing the barrier function of the skin & for postnatal maturation & maintenance of the ocular surface
• role in differentiation of epithelial cells
• may also function in skeletal & kidney development
• contributes to down-regulation of p53/TP53 transcription
• interacts with POU5F1/OCT4 & SOX2 (putative)
• interacts with MUC1 (via the C-terminal domain)

Structure

• the 9aaTAD motif is a transactivation domain present in a large number of yeast & animal transcription factors
• belongs to the krueppel C2H2-type Zn+2-finger protein family
• contains 3 C2H2-type Zn+2 fingers

Compartment

nucleus

Alternative splicing

named isoforms=3

Notes

• KLF4 is one of the four Yamanaka factors

More general terms

• Krueppel-like factor

Additional terms

• Yamanaka factor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9314
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9314
• OMIM: https://mirror.omim.org/entry/602253
• UniProt: http://www.uniprot.org/uniprot/O43474.html