pluripotential stem cell
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Introduction
Primordial stem cells derived from totipotential stem cells of the embryonic morula, first appear as embryonic stems cells of the blastocyst. Pluripotential stem cells can differentiate into cells of any of the 3 germ layers: endoderm, ectoderm, mesoderm. Mesenchymal stem cells are the most prominent pluripotent cell in developing embryos.
Pluripotential stem cells are inducible from differentiated cells (fibroblasts)[2] (see induced pluripotential stem cell)
A cylindrical structure seeded with pluripotential stem cells & exposed to growth factors produced small cylinders of intestinal epithelium & mesenchyme[5]
Also see stem cell
More general terms
More specific terms
- embryonic stem (ES) cell
- induced pluripotent stem cell (iPS)
- mesenchymal cell
- mesenchymal stem cell
- multipotent adult progenitor cell (MAPC)
- pleuripotential hematopoietic stem cell
References
- ↑ Stedman's Medical Dictionary 27th ed, Williams & Wilkins, Baltimore, 1999
- ↑ 2.0 2.1 Takahashi K et al, Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007, Nov 20, 131:861 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/18035408 <Internet> http://dximages.cell.com/images/images/cell/ieps/3661.pdf Yu J et al, Induced pluripotent stem cells derived from human somatic cells. Science 2007, Nov 20 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/18029452 <Internet> http://dx.doi.org/10.1126/science.1151526
- ↑ Wikipedia: Stem cell http://en.wikipedia.org/wiki/Stem_cell
- ↑ Samuel R et al. Generation of functionally competent and durable engineered blood vessels from human induced pluripotent stem cells. Proc Natl Acad Sci U S A 2013 Jul 30 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23861493 <Internet> http://www.pnas.org/content/110/31/12774
Takebe T et al. Vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature 2013 Jul 25; 499:481 PMID: https://www.ncbi.nlm.nih.gov/pubmed/23823721 - ↑ 5.0 5.1 Watson CL et al. An in vivo model of human small intestine using pluripotent stem cells. Nat Med 2014 Nov; 20:1310. PMID: https://www.ncbi.nlm.nih.gov/pubmed/25326803