hyperoxaluria

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Introduction

Autosomal recessive disorder in which homozygotes develop urolithiasis. It is the most aggressive stone disease.

Etiology

* oxalate in almonds > soy bean > rice

Epidemiology

  • rare, type-1

Genetics

Clinical manifestations

Laboratory

Radiology

Management

* pyridoxal phosphate appears to ameliorate deficiency of the liver-specific pyridoxal-phosphate-dependent peroxisomal enzyme alanine:glyoxylate aminotransferase[6]; it is not expected to have any benefit for diet-associated hyperoxaluria

More general terms

More specific terms

Additional terms

References

  1. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 616
  2. Jump up to: 2.0 2.1 2.2 Medical Knowledge Self Assessment Program (MKSAP) 11, 17. American College of Physicians, Philadelphia 1998, 2015
  3. Ellis D, Lieb J. Hyperoxaluria and genitourinary disorders in children ingesting almond milk products. J Pediatr 2015 Sep 14 PMID: https://www.ncbi.nlm.nih.gov/pubmed/26382627
  4. Jump up to: 4.0 4.1 Shekarriz B, Schwartz BF Medsacpe: Hyperoxaluria http://emedicine.medscape.com/article/444683-overview
  5. Jump up to: 5.0 5.1 Terris MK; Issa MM; Tacker JR Dietary supplementation with cranberry concentrate tablets may increase the risk of nephrolithiasis. Urology. 2001; 57(1):26-9 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11164137
  6. Jump up to: 6.0 6.1 Fargue S, Rumsby G, Danpure CJ. Multiple mechanisms of action of pyridoxine in primary hyperoxaluria type 1. Biochim Biophys Acta. 2013 Oct;1832(10):1776-83. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23597595 Free Article
  7. Jump up to: 7.0 7.1 7.2 Jiang D, Geng H (radiograph) Primary Hyperoxaluria N Engl J Med 2017; 376:e33. April 13, 2017 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28402768 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMicm1609986
  8. Jump up to: 8.0 8.1 Massey LK Food Oxalate: Factors affecting measurement, biological variation, and bioavailability. J Am Diet Assoc. 2007 Jul;107(7):1191-4 PMID: https://www.ncbi.nlm.nih.gov/pubmed/17604750

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