glyoxylate reductase/hydroxypyruvate reductasel D-glycerate dehydrogenase; D-glyceric dehydrogenase (GRHPR, GLXR, MSTP035)

Function

• enzyme with hydroxy-pyruvate reductase, glyoxylate reductase & D-glycerate dehydrogenase enzymatic activities

Glycolate + NADP+ <--> glyoxylate + NADPH

Structure

• monomer
• belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family

Expression

• ubiquitous
• most abundantly expressed in the liver

Pathology

• defects in GRHPR are the cause of primary hyperoxaluria type 2

Laboratory

• GRHPR gene mutation

More general terms

• enzyme

Database

• OMIM: https://mirror.omim.org/entry/260000
• OMIM: https://mirror.omim.org/entry/604296
• UniProt: http://www.uniprot.org/uniprot/Q9UBQ7.html