adiponectin; 30 kD adipocyte complement-related protein; adipocyte complement-related 30 kD protein; ACRP30; adipocyte, C1q & collagen domain-containing protein; adipose most abundant gene transcript 1 protein; apM-1; Gelatin-binding protein (ADIPOQ, ACDC, ACRP30, APM1, GBP28)

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Function

Structure

Compartment

secreted, plasma

Expression

Pathology

Polymorphism

  • genetic variations in ADIPOQ influence the variance in adiponectin serum levels & define the adiponectin serum levels quantitative trait locus 1 (ADIPQTL1) [MIM:612556]

Pharmacology

Comparative biology

Notes

  • variants Arg-84 & Ser-90 show impaired formation of HMW complexes whereas variants Cys-112 & Thr-164 show impaired secretion of adiponectin in any form
  • HMW-complex blood contents are higher in females than in males, are increased in males by castration & decreased again upon subsequent testosterone treatment, which blocks HMW-complex secretion (putative)
  • in patients with diabetes mellitus type 2 both the ratios of HMW to total adiponectin & the degree of adiponectin glycosylation are significantly decreased as compared with healthy controls

More general terms

References

  1. Barbara Hansen, University of Maryland, AGE Meeting, Madison, WI, June 2001
  2. Journal Watch 21(17):141, 2001 Berg AH et al The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 7:947, 2001 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11479628
  3. UniProt http://www.uniprot.org/uniprot/Q15848.html
  4. Wikipedia; Note: adiponectin entry http://en.wikipedia.org/wiki/adiponectin
  5. 5.0 5.1 5.2 Okada-Iwabu M et al. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature 2013 Nov 28; 503:493 PMID: https://www.ncbi.nlm.nih.gov/pubmed/24172895
  6. 6.0 6.1 Komaroff AL Understanding the Pathogenesis of Polycystic Ovary Syndrome NEJM Journal Watch. March 10, 2015 Massachusetts Medical Society (subscription needed) http://www.jwatch.org
    Yuan X et al. Brown adipose tissue transplantation ameliorates polycystic ovary syndrome. Proc Natl Acad Sci U S A 2016 Mar 8; 113:2708 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26903641 <Internet> http://www.pnas.org/content/113/10/2708

Database