histopathology of Alzheimer's disease

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Pathology

Abnormal morphologic structures:

* see figure A neurofibrillary tangles & figure B neuritic plaque

Other:

* suggestion is made that synaptic dysfunction rather than synaptic or neuronal loss is implicated in Alzheimer's dementia[10]

* elevated vascular risk may influence tau burden when coupled with high beta-amyloid burden[12]

Diagnostic criteria

  • six stages distinguished by location and severity of changes
    • trans-entorhinal stages I-II: clinically silent
      • involvement confined
    • limbic stages III-IV: incipient AD
      • involvement of CA1
    • neocortical stages V-VI: fully developed AD

* microglial activation & PHF-tau propagate jointly across Braak stages[14]

Notes

More general terms

More specific terms

Additional terms

References

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