Hirano body

Introduction

Intracellular paracrystalline rod like structures seen in aging, neurodegenerative diseases such as Alzheimer's disease, Pick's disease, kuru & alcoholism; composed of actin & actin binding proteins. Oxidation of cofilin-1 may result in abnormal actin-bundling activity & play a role in formation of Hirano bodies. Components of Hirano bodies include: actin alpha-actinin destrin cofilin-1 neurofilament tropomyosin vinculin microtubule-associated protein tau MAP-1 MAP-2

More general terms

• abnormal morphologic structure (malformation)

Additional terms

• cofilin-1; cofilin, non-muscle isoform; 18 kD phosphoprotein; p18 (CFL1 CFL)