cyclin-dependent kinase-13 (CDK13); CDC2-related protein kinase 5; cell division cycle 2-like protein kinase 5; cell division protein kinase 13; hCDK13; cholinesterase-related cell division controller (CDC2L, CDC2L5, CHED, KIAA1791)

Function

• cyclin-dependent kinase
• displays CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thus acting as a regulator of transcription elongation
• required for RNA splicing, probably by phosphorylating SRSF1/SF2
• required during hematopoiesis
• phosphorylated upon DNA damage, probably by ATM or ATR
• interacts with CCNL1 & CCNL2 (putative)
• interacts with C1QBP
• interacts with HIV-1 Tat

Structure

• belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
• contains 1 protein kinase domain

Compartment

nucleus speckle

Alternative splicing

named isoforms=2

Expression

• expressed in fetal brain, liver, muscle & in adult brain
• also expressed in neuroblastoma & glioblastoma tumors

Pathology

• in case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at Lys-50 & Lys-51, thus increasing HIV-1 mRNA splicing & promoting production of the doubly spliced HIV-1 protein Nef

More general terms

• cyclin-dependent kinase (CDK)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8621
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8621
• OMIM: https://mirror.omim.org/entry/603309
• UniProt: http://www.uniprot.org/uniprot/Q14004.html