C1Q-binding protein, mitochondrial; GC1q-R protein; glycoprotein gC1qBP; C1qBP; hyaluronan-binding protein 1; mitochondrial matrix protein p32; p33 (C1QBP, GC1QBP, HABP1, SF2P32)

Function

• binds to the globular heads of C1Q thus inhibiting C1 activation
• interacts with CDK13
• interacts with HRK

Structure

belongs to the MAM33 family

Compartment

• mitochondrial matrix
• nucleus (might also be nuclear in some cell types)

Pathology

• interacts with Rubella virus capsid protein
• interacts with HIV-1 Tat

Notes

• originally thought to be a pre-mRNA splicing factor SF2 p32 subunit with role in preventing exon skipping, ensuring accuracy of splicing & regulating alternative splicing

More general terms

• mitochondrial protein
• hyaluronan-binding protein
• phosphoprotein

Additional terms

• complement C1q

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=708
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:708
• OMIM: https://mirror.omim.org/entry/601269
• UniProt: http://www.uniprot.org/uniprot/Q07021.html