Cyclin-L2; paneth cell-enhanced expression protein (CCNL2)

Function

• transcriptional regulator
• regulation of pre-mRNA splicing process.
• modulates expression of critical apoptotic factor
• interacts with CDC2L1, CDC2L2, SFRS2, SFRS7
• interacts with the hyperphosphorylated C-terminal domain (CTD) of POLR2A

Structure

• contains a RS region (Arg-Ser dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors
  • this region probably plays a role in protein-protein interactions
• belongs to the cyclin family, cyclin L subfamily

Compartment

nucleus, nucleoplasm; nuclear speckle

Alternative splicing

named isoforms=3

Expression

• ubiquitously expressed
• higher expression level observed in ovary, heart, liver, pancreas

More general terms

• cyclin L

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=81669
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:81669
• OMIM: https://mirror.omim.org/entry/613482
• UniProt: http://www.uniprot.org/uniprot/Q96S94.html