WNT1-inducible-signaling pathway protein 1; WISP-1; Wnt-1-induced secreted protein (WISP1 CCN4)

Function

• downstream regulator in the Wnt/Frizzled-signaling pathway
• associated with cell survival
• attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase
• up-regulates the anti-apoptotic Bcl-X(L) protein
• adheres to skin & melanoma fibroblasts
• in vitro binding to skin fibroblasts occurs through the proteoglycans, decorin & biglycan

Structure

• belongs to the CCN family
• contains 1 CTCK (C-terminal cystine knot-like) domain
• contains 1 IGFBP N-terminal domain
• contains 1 TSP type-1 domain
• contains 1 VWFC domain

Compartment

secreted

Alternative splicing

named isoforms=2

Expression

• expressed in heart, kidney, lung, pancreas, placenta, ovary, small intestine & spleen
• isoform 2 is weakly expressed in placenta

Pathology

• overexpression is associated with several cancers including: breast cancer & colon tumors
• isoform 2 is overexpressed in scirrhous gastric carcinoma

More general terms

• WNT1 inducible signaling pathway protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8840
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8840
• OMIM: https://mirror.omim.org/entry/603398
• UniProt: http://www.uniprot.org/uniprot/O95388.html