Decorin; bone proteoglycan II; PG-S2; PG40 (DCN SLRR1B)

Function

• proteoglycan core protein
• binds to type 1 collagen & type 2 collagen, fibronectin & TGF-beta
• may affect the rate of fibrils formation
• attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin
• forms a ternary complex with MFAP2 & ELN
• interacts with DPT (putative)

Structure

• belongs to the small leucine-rich proteoglycan (SLRP) family, class I subfamily
• contains 12 LRR repeats (leucine-rich repeats)

Compartment

• secreted, extracellular space, extracellular matrix

Alternative splicing

named isoforms=5; A,B,C,D,E

Expression

TGF-beta stimulates decorin synthesis

Pathology

• defects in DCN are the cause of congenital stromal corneal dystrophy (CSCD)

More general terms

• proteoglycan core protein
• matrix protein

Database

• UniProt: http://www.uniprot.org/uniprot/P07585.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1634
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1634
• OMIM: https://mirror.omim.org/entry/125255
• OMIM: https://mirror.omim.org/entry/610048