dermatopontin; tyrosine-rich acidic matrix protein; TRAMP (DPT)

Function

• seems to mediate adhesion by cell surface integrin binding
• may serve as a communication link between the dermal fibroblast cell surface & its extracellular matrix environment
• enhances TGFB1 activity
• inhibits cell proliferation
• accelerates collagen fibril formation, & stabilizes collagen fibrils against low-temperature dissociation (putative)
• sulfated on Tyr (putative)
• interacts with TGFB1, DCN & collagen (putative)

Structure

• belongs to the dermatopontin family

Compartment

• secreted, extracellular space, extracellular matrix (putative)

Expression

• expressed in fibroblasts, heart, skeletal muscle, brain & pancreas
• expressed at an intermediate level in lung & kidney
• expressed at a low level in liver & placenta
• expressed at a lower level in fibroblasts from hypertrophic scar lesional skin & in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts
• induced by TGFB1, repressed by IL4/interleukin-4

More general terms

• secreted protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1805
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1805
• OMIM: https://mirror.omim.org/entry/125597
• UniProt: http://www.uniprot.org/uniprot/Q07507.html