megestrol (Megace)

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Introduction

Tradename: Megace. Pregnancy risk category: X

Indications

* does not improve quality of life or mortality in cance patients[4]

Contraindications

Caution:

pregnancy category = d

pregnancy category = x

safety in lactation = ?

Dosage

  • start: 80-160 mg daily in 4 divided doses
  • maintenance: 400-800 mg PO QD
  • up to 1600 mg/day

Tablets: 20 mg, 40 mg

Suspension: 40 mg/mL in alcohol 0.06% (240 mL)

Adverse effects

Test interactions

altered thyroid & liver function tests

Laboratory

Mechanism of action

More general terms

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  3. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  4. 4.0 4.1 4.2 Medical Knowledge Self Assessment Program (MKSAP) 11, 16, 18, 19 American College of Physicians, Philadelphia 1998, 2012, 2018, 2022
  5. 5.0 5.1 Bruera & Neumann Canadian Medical Assoc. J (CAMJ):158:1717, 1998
  6. 6.0 6.1 Leinung MC, Liporace R, Miller CH. Induction of adrenal suppression by megestrol acetate in patients with AIDS. Ann Intern Med. 1995 Jun 1;122(11):843-5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7741369
  7. 7.0 7.1 Deprecated Reference
  8. Ruiz Garcia V, Lapez-Briz E, Carbonell Sanchis R et al Megestrol acetate for treatment of anorexia-cachexia syndrome. Cochrane Database Syst Rev. 2013 Mar 28;(3):CD004310. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23543530
  9. 9.0 9.1 Geriatric Review Syllabus, 10th edition (GRS10) Harper GM, Lyons WL, Potter JF (eds) American Geriatrics Society, 2019

Database