ligand-dependent corepressor; LCoR; Mblk1-related protein 2 (LCOR, KIAA1795, MLR2)

Function

• transcription activator (putative) -binds DNA sequence 5'-CCCTATCGATCGATCTCTACCT-3'
• represses of ligand-dependent transcription activation by target nuclear receptors
  • ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA, VDR
• interacts with ESR1, ESR2 in the presence of estradiol
• interacts with CTBP1, HDAC3, HDAC6
• component of large corepressor complex

Structure

contains 1 HTH psq-type DNA-binding domain

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

ubiquitous

More general terms

• transcriptional silencer (transcriptional repressor)
• transcriptional adaptor protein; transcriptional coactivator
• DNA-binding protein
• phosphoprotein

Component of

• corepressor complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84458
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:84458
• OMIM: https://mirror.omim.org/entry/607698
• UniProt: http://www.uniprot.org/uniprot/Q96JN0.html