retinoic acid receptor gamma; RAR-gamma; nuclear receptor subfamily 1 group B member 3 (RARG, NR1B3)
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Function
- receptor for retinoic acid
- role in vertebrate development
- retinoic acid is a morphogen & a teratogen
- controls cell function by directly regulating gene expression
- forms a complex with PUS1 & the SRA1 RNA in the nucleus
Structure
- composed of three domains:
- modulating N-terminal domain
- DNA-binding domain
- C-terminal steroid-binding domain
- belongs to the nuclear hormone receptor family, NR1 subfamily
- contains 1 nuclear receptor DNA-binding domain
Compartment
Alternative splicing
named isoforms=2
isoforms differ only in their N-terminal regions
More general terms
More specific terms
References
- ↑ Sporn MB, Roberts AB. Interactions of retinoids and transforming growth factor-beta in regulation of cell differentiation and proliferation. Mol Endocrinol. 1991 Jan;5(1):3-7. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2017191
- ↑ Green S. Nuclear hormone receptors. Promiscuous liaisons. Nature. 1993 Feb 18;361(6413):590-1. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8382343
- ↑ Wikipedia; Note: retinoic acid receptor entry http://en.wikipedia.org/wiki/retinoic_acid_receptor
- ↑ UniProt http://www.uniprot.org/uniprot/P13631.html