serglycin; secretory granule proteoglycan core protein; platelet proteoglycan core protein; P.PG; hematopoietic proteoglycan core protein (SRGN, PRG, PRG1)
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Function
- proteoglycan core protein of heparin[3]
- role in formation of mast cell secretory granules & mediates storage of various compounds in secretory vesicles
- required for storage of some proteases in both connective tissue & mucosal mast cells & for storage of granzyme B in T lymphocytes
- role in localizing neutrophil elastase in azurophil granules of neutrophils
- mediates processing of MMP2
- role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis
- regulates the secretion of TNF-alpha & may also regulate protease secretion
- inhibits bone mineralization
- binds to activated CD44 & to GZMB
Structure
- O-glcosylated
- contains chondroitin sulfate & heparan sulfate (putative)
- belongs to the serglycin family
Compartment
- cytoplasmic granule (putative)
- secreted, extracellular space
- Golgi
- found in mast cell granules & in cytoplasmic granules of cytolytic T lymphocytes from where it is secreted upon cell activation
- located to Golgi apparatus during neutrophil differentiation
Expression
- secreted from activated cytolytic T lymphocytes
- secreted constitutively by endothelial cells & macrophages
- induced by EBV
More general terms
Component of
References
- ↑ UniProt http://www.uniprot.org/uniprot/P10124.html
- ↑ Ruoslahti E, Yamaguchi Y. Proteoglycans as modulators of growth factor activities. Cell. 1991 Mar 8;64(5):867-9. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2001586
- ↑ 3.0 3.1 Salmivirta M, Lidholt K, Lindahl U. Heparan sulfate: a piece of information. FASEB J. 1996 Sep;10(11):1270-9. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8836040