elastase-2; neutrophil elastase; leukocyte elastase; medullasin; bone marrow serine protease ( ELA2, ELANE)
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Function
- modifies functions of natural killer cells, monocytes & granulocytes
- inhibits C5a-dependent neutrophil enzyme release & chemotaxis
- hydrolysis of proteins, including elastin
- preferential cleavage: Val-|-Xaa > Ala-|-Xaa
Structure
Expression
Pathology
- defects in ELA2 are a cause of cyclic hematopoiesis
Genetics
- proteinase 3, neutrophil elastase & azurocidin are within an approximately 50-kb cluster on chromosome 19p
Laboratory
More general terms
More specific terms
References
- ↑ OMIM https://mirror.omim.org/entry/130130
- ↑ UniProt http://www.uniprot.org/uniprot/P08246.html
- ↑ ELA2base; ELA2 mutation db http://bioinf.uta.fi/ELA2base/
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=ELA2
- ↑ Wikipedia; Note=elastase entry http://en.wikipedia.org/wiki/elastase