elastase-2; neutrophil elastase; leukocyte elastase; medullasin; bone marrow serine protease ( ELA2, ELANE)

Function

• modifies functions of natural killer cells, monocytes & granulocytes
• inhibits C5a-dependent neutrophil enzyme release & chemotaxis
• hydrolysis of proteins, including elastin
• preferential cleavage: Val-|-Xaa > Ala-|-Xaa

Structure

• belongs to the peptidase S1 family, elastase subfamily
• contains 1 peptidase S1 domain

Expression

bone marrow cells

Pathology

• defects in ELA2 are a cause of cyclic hematopoiesis

Genetics

• proteinase 3, neutrophil elastase & azurocidin are within an approximately 50-kb cluster on chromosome 19p

Laboratory

• leukocyte elastase in plasma

More general terms

• serine protease elastase
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P08246.html
• OMIM: https://mirror.omim.org/entry/130130
• OMIM: https://mirror.omim.org/entry/162800
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1991