calmodulin-2 (CALM2, CAM2 CAMB)

Function

• calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins & other proteins through Ca+2-binding
• among the enzymes to be stimulated by the calmodulin-Ca+2 complex are a number of protein kinases & phosphatases
• together with CCP110 & centrin, is involved in a genetic pathway that regulates the centrosome cycle & progression through cytokinesis
• mediates Ca+2-dependent inactivation of CACNA1C
• positively regulates Ca+2-activated K+ channel activity of KCNN2
• interacts with MYO1C, MYO5A & RRAD
• interacts with MYO10 (putative)
• interacts with CEP97, CCP110, TTN/titin & SRY
• interacts with USP6, CDK5RAP2, SCN5A (putative)
• interacts with RYR1, FCHO1
• interacts with MIP & promotes MIP water channel closure (putative)
• interacts with ORAI1, IQCF1, SYT7 (putative)
• interacts with CEACAM1, RYR2, PCP4
• interacts with the heterotetrameric KCNQ2 & KCNQ3 channel
• ubiquitination results in a strongly decreased activity
• phosphorylation results in a decreased activity

Structure

• belongs to the calmodulin family,
• 4 functional Ca+2-bindingsites

Compartment

• cytoplasm, cytoskeleton, spindle, spindle pole
• distributed throughout the cell during interphase
• during mitosis becomes localized to the spindle poles & the spindle microtubules

Pathology

• mutations in CALM2 are the cause of long QT syndrome type 15

More general terms

• calmodulin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=801
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=805
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=808
• OMIM: https://mirror.omim.org/entry/114182
• OMIM: https://mirror.omim.org/entry/616249
• UniProt: http://www.uniprot.org/uniprot/P0DP24.html