K+ channel subfamily N member 2; small conductance Ca+2-activated K+ channel protein 2; SK2; SKCa 2; SKCa2; KCa2.2 (KCNN2)

Function

• voltage-independent K+ channel activated by intracellular Ca+2
• intermediate/small conductance
• activation is followed by membrane hyperpolarization
• regulates neuronal excitability by contributing to slow component of synaptic after hyperpolarization
• channel is blocked by apamin

Structure

• hetero-oligomer
• 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through Ca+2-binding
• belongs to the K+ channel KCNN family KCa2.2/KCNN2 subfamily

Compartment

membrane

Expression

widely expressed

More general terms

• transmembrane 6 protein
• calmodulin binding protein
• K+ channel subfamily N

Component of

• Ca+2-activated K+ channel

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3781
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3781
• OMIM: https://mirror.omim.org/entry/605879
• UniProt: http://www.uniprot.org/uniprot/Q9H2S1.html