CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48, centrosome-associated protein 215, CDK5RAP2, CEP215, KIAA1633)

Function

• regulates CDK5 activity via its interaction with CDK5R1 (putative)
• phosphorylated in vitro by CDK5
• interacts with CDK5R1 (p35 form)
  • CDK5RAP1, CDK5RAP2 & CDK5RAP3 show competitive binding to CDK5R1
• forms complex with CDK5R1 & CDK5 (putative)

Compartment

centrosome

Alternative splicing

named isoforms=4

Expression

• widely expressed
• expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas

More general terms

• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/608201
• UniProt: http://www.uniprot.org/uniprot/Q96SN8.html