CDK5 regulatory subunit-associated protein 1; CDK5 activator-binding protein C42 (CDK5RAP1)

Function

• specifically inhibits CDK5 activation by CDK5R1
• binds 1 4Fe-4S cluster
  • cluster is coordinated with 3 cysteines & an exchangeable S-adenosyl-L-methionine (putative)
• interacts with CDK5R1 (p35 form)
  • CDK5RAP1, CDK5RAP2 & CDK5RAP3 competitively binding to CDK5R1
• forms a complex with CDK5R1 & CDK5

Structure

• belongs to the UPF0004 family, CDK5RAP1 subfamily
• contains 1 TRAM domain

Alternative splicing

named isoforms=4

Expression

• widely expressed
• expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney & pancreas

More general terms

• other protein

Database

• OMIM: https://mirror.omim.org/entry/608200
• UniProt: http://www.uniprot.org/uniprot/Q96SZ6.html