CDK5 regulatory subunit-associated protein 3; CDK5 activator-binding protein C53; LXXLL/leucine-zipper-containing ARF-binding protein; HSF-27 protein (CDK5RAP3 IC53, MSTP016, OK/SW-cl114, PP1553)

Function

• regulates CDK5 activity via its interaction with CDK5R1 (putative)
• cell proliferation
• interacts with CDK5R1, enteric adenovirus serotype 41 fiber protein
• phosphorylated in vitro by CDK5
• ubiquitinated
• probably triggers proteasomal degradation
• negatively regulated by UFL1
• may be ufmylated
• interacts with CDK5R1
• CDK5RAP1, CDK5RAP2 & CDK5RAP3 competitively bind to CDK5R1 (putative)
• interacts with UFL1
• interacts with DDRGK1

Structure

belongs to the CDK5RAP3 family,

Alternative splicing

named isoforms=4

Expression

• ubiquitous
• expressed in heart, brain,placenta, lung, liver, skeletal muscle, kidney, pancreas
• isoform 3 is expressed in kidney, liver, skeletal muscle, placenta

More general terms

• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=80279
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:80279
• OMIM: https://mirror.omim.org/entry/608202
• UniProt: http://www.uniprot.org/uniprot/Q96JB5.html