Ca+2 release-activated Ca+2 channel protein 1 (transmembrane protein 142A, protein orai-1, TMEM142A, CRACM1, ORAI1)

Function

• Ca+2 release-activated Ca+2 channel (CRAC channel) subunit

Compartment

cell membrane

Pathology

• defects in CRACM1 associated with severe combined immunodeficiency

Notes

• in Greek mythology, the 'Orai' are the keepers of the gates of heaven

More general terms

• Ca+2 binding protein
• transmembrane 4 protein

Component of

• Ca+2 release-activated Ca+2 channel (CRAC channel)

Database

• UniProt: http://www.uniprot.org/uniprot/Q96D31.html