Ca+2 release-activated Ca+2 channel (CRAC channel)

Function

• mediates Ca+2 influx following depletion of intracellular Ca+2 stores
• channel activation by the Ca+2 sensor, STIM1
• main pathway for Ca+2 influx in T-cells
  • promote the immune response to pathogens by activating transcription factor NFAT

Structure

subunits: CRACM1

Compartment

cell membrane

More general terms

• molecular complex