syntenin-1; syndecan-binding protein 1; melanoma differentiation-associated protein 9; MDA-9; scaffold protein Pbp1; Pro-TGF-alpha cytoplasmic domain-interacting protein 18; TACIP18 (SDCBP, MDA9, SYCL)
Jump to navigation
Jump to search
Function
- seems to function as an adapter protein
- in adherens junctions, may function to couple syndecans to cytoskeletal proteins or signaling components
- seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA/CD125)
- may also play a role in vesicular trafficking
- seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway
- binds to cytoplasmic domains of syndecans & pro TGF-alpha
- phosphorylated on Tyr
- interacts with SDC1, SDC2, SDC3, SDC4, NRXN2, EPHA7, EPHB1, NF2 isoform 1, TGFA & IL5RA
- interacts with neurofascin, SDCBP2 & PTPRJ
Structure
- monomer & homodimer (putative)
- contains 2 PDZ domain (DHR domain)s
Compartment
- cell junction, focal adhesion, adherens junction
- peripheral membrane
- endoplasmic reticulum membrane
- melanosome (stage 1-4)
- cytoplasm, cytoskeleton
- mainly membrane-associated
- localized to adherens junctions, focal adhesions & endoplasmic reticulum
- colocalized with actin stress fibers
- also found in nucleus
Alternative splicing
named isoforms=3
Expression
- widely expressed
- expressed in fetal kidney, liver, lung & brain
- in adult, highest expression in heart & placenta
- induced by gamma interferon in melanoma cells