syndecan-3; SYND3 (SDC3 KIAA0468)

Function

• cell surface proteoglycan that may bear heparan sulfate
• plasma membrane embedded proteoglycan core protein
• may have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface (sugar-dependent)
• O-glycosylated within the Thr/Ser-rich region which probably interacts with lectin domains on other molecules

Structure

belongs to the syndecan proteoglycan family

Compartment

plasma membrane

Alternative splicing

named isoforms=3

Expression

• expressed in the nervous system, adrenal gland, & spleen

More general terms

• proteoglycan core protein
• plasma membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9672
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9672
• OMIM: https://mirror.omim.org/entry/186357
• UniProt: http://www.uniprot.org/uniprot/O75056.html