receptor-type tyrosine-protein phosphatase eta; protein-tyrosine phosphatase eta; R-PTP-eta; density-enhanced phosphatase 1; DEP-1; HPTP eta; protein-tyrosine phosphatase receptor type J; R-PTP-J; CD148 (PTPRJ, DEP1)

Function

• may contribute to the mechanism of contact inhibition of cell growth

protein tyrosine phosphate + H2O = protein tyrosine + phosphate

Structure

• N- & O-glycosylated
• belongs to the protein-tyrosine phosphatase family receptor class 3 subfamily
• contains 9 fibronectin F3 modules
• contains 1 tyrosine-protein phosphatase domain

Compartment

• membrane; single-pass type 1 membrane protein

Expression

• expressed in the promyelocytic cell line HL60, the granulocyte-macrophage colony-stimulating factor-dependent leukemic cell line F-36P, & the interleukin-3 & erythropoietin-dependent leukemic cell line F-36E

More general terms

• tyrosine phosphatase, receptor type
• CD antigen

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5795
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5795
• OMIM: https://mirror.omim.org/entry/600925
• UniProt: http://www.uniprot.org/uniprot/Q12913.html